The title above is from an excellent article in The Atlantic by … [Read More...] about The Worse the Pandemic Gets, the Weirder It Will Get, By Jessica Dabler Martin In conclusion, through a systematic approach and meta‐analysis, we demonstrate that sIgE to hazelnut storage proteins Cor a 14 and Cor a 9 confers specificity in the diagnosis of hazelnut allergy in children. Future analyses of the contribution of additional hazelnut allergen components are needed, as well as evaluations in adult populations. During an anaphylactic attack, the chemicals released by the immune system can cause the blood pressure to drop suddenly, and the airways to narrow thus, blocking normal breathing. If you are diagnosed with hazelnut allergy, you must completely avoid all foods and beverages that contain hazelnuts and other birch nuts. The pediatric subanalyses were presented as forest plots and as summary receiver‐operating characteristic (sROC) plots. This likely reflects the role of storage proteins as early sensitizers and markers of hazelnut allergy.32-34 The results presented are the first meta‐analysis data focusing on hazelnut allergen components, but a previous systematic review on CRD in food allergies35 and studies on peanut and other tree nut allergies (cashew and walnut) together show that the respective 2S albumins have high accuracy in identifying children with allergies and objective symptoms.36-39. To avoid a reaction, avoid exposure to hazelnuts and other particles that may trigger the allergy. Food allergies can be debilitating conditions that limit not only your diet but your exposure to other products as well. Therefore, the patient needs to be taken to the hospital at the earliest, as a second reaction may occur up to 4 hours or longer post the first one. Hazelnut belongs to the birch family, as do the hickory nut and filbert. The Journal of Allergy and Clinical Immunology: In Practice. Sure enough, hazelnuts have two “storage” proteins—Cor a 9 and Cor a 14 that are “associated with severe reactions.” Both are stable to heat and digestion. Typically, a first allergic reaction to nuts occurs between 14 months and 2 years of age. Mild reactions include tingling in the mouth, face or throat, edema (swelling), feeling ill, rashes or hives, upset stomach, and tightness in the throat area. All pediatric studies were cross‐sectional designs, resembling the clinical situation and minimizing the risk of overestimating diagnostic parameters.48 This meta‐analysis is limited by the small number of articles retrieved, but the datasets still enabled a reliable meta‐analysis with low heterogeneity. To make matters more confusing, it is also possible that the spike in IgE had more to do with the fact that Easter coincides with the onset of pollen season. Tree nut allergies affect 1.2% of children and adults,1, 2 and hazelnut allergy is among the most common of these allergies. I went to the Thermo Fisher Scientific website for some clarity. The symptoms and treatment of the condition have been briefly discussed as follows. New Research Presents Progress in Controlling Peanut Allergy Reactions, Learn more. A concomitant birch pollen allergy was more common in adults (82%) than in children (39%) with a hazelnut allergy. Our aim was to compare the diagnostic accuracy of sIgE to available hazelnut storage proteins and the pollen cross‐reactive PR‐10 Cor a 1 and LTP Cor a 8 proteins in patients suspected of hazelnut allergy through a systematic approach. The clinical implications of the key findings from the diagnostic meta‐analyses were calculated and projected using the average disease prevalence from the included pediatric studies to estimate the percentage of children who would be accurately diagnosed with hazelnut components at 0.10, 0.35, and 1.0 kUA/L cutoffs. The reviewers assessed risk of bias of the included studies using 11 quality items listed in the Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy,20 plus two additional quality items of importance for this review (“Were cutoff values established before the study was started?” and “Was the study free of commercial funding?”). This allergic can range from mild, severe to life-threatening. In contrast, the pooled specificities of Cor a 9 (74.1% [63.2, 82.6]) and Cor a 14‐sIgE (84.9% [79.4, 89.2]) were significantly (P < .05) higher than for Cor a 1‐sIgE 20.3% ([7.9, 43.0]). She began writing professionally in 2004 and has written for several websites including Wound Care Centers and That was when the test extracts were analyzed. Hazelnut‐specific IgE antibodies (sIgEs) in serum support the diagnosis of hazelnut allergy, but extract‐based tests have low diagnostic specificity, commonly leading to over‐diagnosis. Fascinating stuff, Henry! Paleo Autoimmune Protocol: What Does it Mean. The DOR for Cor a 14 at 0.35 kUA/L was 20.36 while that of Cor a 9 at 1.0 kUA/L was 16.96 (Table 2). Readily available hazelnut component tests include storage proteins Cor a 9 and Cor a 14, and the cross‐reactive proteins Cor a 1 (PR‐10) and Cor a 8 (lipid transfer protein, LTP).12, 13 Other hazelnut components are the 7S‐vicilin‐like protein Cor a 1114 and two oleosins (Cor a 12 and Cor a 13), to which sensitization has been demonstrated, although their clinical relevance has not been confirmed.12.